Response of patients with hemophilia A and von Willebrand disease to desmopressin (DDAVP)
Bol. Asoc. Méd. P. R
;
82(5): 207-10, maio 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-92368
ABSTRACT
Factor VIII (FVIII) response to desmopressin (deamino-8-D-arginine vasopressin, abbreviated DDAVP) was studied in patients with mild Hemophilia A and von Willebrand Disease (vWD) who attend our Hemophilia Clinic. Thirty eight children and 9 adults had their F VIII components assayed 60 minutes after intravenous (IV) administration of DDAVP, 0.35 ug/kg. Among 27 hemophiliacs, F VIII coagulant activity (F VIII C) increased from a mean of 16.8 to 59.2 u/dL; with an average 3.2-fold increase. In 20 vWD patients, the mean F VIIIC and von Willebrand Factor increased from a mean of 50.1 to 136%; and from 22.6 to 75.6%; with an average 3.0 and 5.7-fold increase, respectively. The overall F VIIIC response was good or excellent in 81.5% of the hemophiliaacs, and in 89.5% of the vWD patients tested. No significant side effects were observed. This study has demonstrated that IV DDAVP can cause an increase of F VIIIC and vWF to hemostatic levels, and thus it may be useful for the control of bleeding episodes in most of the patients tested in our clinic
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Índice:
LILACS (Américas)
Assunto principal:
Doenças de von Willebrand
/
Desamino Arginina Vasopressina
/
Hemofilia A
Limite:
Adulto
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Bol. Asoc. Méd. P. R
Assunto da revista:
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
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