Exogenous ganglioside stimulation of axonal regeneration after new transection and entubulation repair
Braz. j. med. biol. res
;
23(9): 823-6, 1990. ilus
Artigo
em Inglês
| LILACS
| ID: lil-92403
ABSTRACT
Adult male mice received sciatic nerve transection at the midthigh level and both nerve stumps were sutured into a polythylene tube (PT) to bridge a nerve gap of 4 mm. The tubes were implanted either empty, or filled with collagen alone or in combination with gangliosides (GM1, GD1a, GD1b, anhd GT1b). Following a survival time of 6 weeks, the PT with the regenerating nerve cables were processed for plastic embedding, and morphometric measurements were made on myelinated and unmyelinated axons. The data suggest that local application of exogenous gangliosides causes a stimulation of axonal sprouting in vivo with no effefct on the rate of axonal maturation
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LILACS (Américas)
Assunto principal:
Nervo Isquiático
/
Gangliosídeos
/
Regeneração Nervosa
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1990
Tipo de documento:
Artigo
/
Congresso e conferência
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