Pharmacokinetic profile of tert-butylaminoethanethiol
Mem. Inst. Oswaldo Cruz
;
85(3): 353-6, jul.-set. 1990. tab
Artigo
em Inglês
| LILACS
| ID: lil-93599
RESUMO
A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug area under the intravenous curve (AUC i.v.) 443(+ ou -) 24.0; AUC oral 85.5(+ ou -) 14.5 ug min.ml(elevado a -1); elimination rate constant 0.069(+ ou -) 0.0055 min(elevado a -1), biological half-life 10.0(+ ou -) 0.80 min; distribution volume 1.15(+ ou -) 0.15 ml/g; biodisponibility 0.19(+ ou -) 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Butilaminas
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1990
Tipo de documento:
Artigo
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