Expresión inmunohistoquímica del antígeno carcinoembrionario en el cáncer de la vesícula biliar / Immunohistochemical expression of the carcinoembryonic antigen in gallbladder cancer
Rev. méd. Chile
;
119(2): 129-36, feb. 1991. tab
Artigo
em Espanhol
| LILACS
| ID: lil-98194
ABSTRACT
Immunohistochemical techniques using monoclonal antibodies were used to investigate the carcinoembryonic antigen (CEA) in gallbladders from 26 patients with gallbladdeer cancer and 26 patients without cacer, including normal mucosa, areas of pyloric metaplasia and areas identified by the presence of "clear cells". All carcinomas were strongly positive for CEA but 61% of noncancerous samples were also positive. However, only 1 of the last samples was strongly positive. According to hystologic type the positivity for CEA in noncancerous samples was 6/11 in normal mucosa, 6/8 in samples with intestinal metaplasia and 1/8 in samples with pyloric metaplasia (p < 0.05). Thus a negative reaction for CEA is 100% specific for absence of cancer. If mild reactions are disregarded, strong reaction for CEA is 81% specific for cancer
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Índice:
LILACS (Américas)
Assunto principal:
Antígeno Carcinoembrionário
/
Biomarcadores Tumorais
/
Neoplasias da Vesícula Biliar
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
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