Efectos del ácido ursodeoxicólico en pacientes con colestasis gravídica / Effects of ursodeoxycholic acid in patients with cholestasis of pregnancy
Rev. méd. Chile
;
119(2): 169-71, feb. 1991. tab
Artigo
em Espanhol
| LILACS
| ID: lil-98201
ABSTRACT
In an open, pilot study, the efficancy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy was investigated. four patients received 1 g/ñday of UDCA during 20 days and another 2 patients received identical periods of treatment separated by a 14-day interval free of drug. Pruritus and serum levels of toal bile salts and glutamic-pyruvic transaminase improved significantly during treatment with UDCA. Although pruritus and the laboratory alterations had a relapse in the second week after UDCA was discontinued, they improved again in the patients who received a second treatment with UDCA. No adverse reactions were detected in the mothers or in their babies. All neuborns are thriving normally, in a follow-up lasted 3 to 6 months after delivery. It is concluded that UDCA appears to be safe when administered in late pregnancy; its primising efficacy in the treatment of intrahepatic cholestasis of pregnancy should now be confirmed in controlled clinical trials
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Índice:
LILACS (Américas)
Assunto principal:
Complicações na Gravidez
/
Ácido Ursodesoxicólico
/
Colestase Intra-Hepática
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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