El endotelio y la circulación coronaria / The endothelium and the coronary circulation
Rev. méd. Chile
;
119(2): 189-96, feb. 1991. tab
Artigo
em Espanhol
| LILACS
| ID: lil-98206
ABSTRACT
In the last few years, so many different substances produced by the endothelium have been discovered that this structure is considered today a parafcrine organ. Among these substances, there are at least three with marked vascular effects prostacyclin (PGI-2) and the endothelium-derived relaxing factor (EDRF) are vasodilators, platelet stabilizers and anti-atherogenic. On the other hand, endothelin-1 (ET-1) is a potent vasoconstrictor and probably pro-atherogenic. There are many agents that stimulate the liberation of these substances by the endothelium and most of then stimulate simultaneously the production of the three substances. even thought it is not possible yet to define the exact participation of the endothelium in the normal regulation of coronary blood flow it is highly probably that a disfunction of this structure secondary to hypercolesterolemia, hypertension, atheromatosis, diabetes and smoking may decrease the coronary reserve, induce coronary spasm and facilitates the development of atheroma
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Índice:
LILACS (Américas)
Assunto principal:
Epoprostenol
/
Circulação Coronária
/
Fatores Relaxantes Dependentes do Endotélio
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
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