Use of y-chromosome-specific DNA probes to evaluate an XX male
Braz. j. med. biol. res
;
24(2): 149-56, 1991. tab
Artigo
em Inglês
| LILACS
| ID: lil-99449
ABSTRACT
The function of a Y human chromosomal DNA sequence was evaluated. The Y-5 probe was isolated from a flow-sorted chromosome library and detects Y-specific sequences. The Y-5 probe and other T-specific probes were used to analyze an XX male patient without ambiguous genitalia. DNA sequences from the short arm of the chromosome Y that were detected with pDP1007 and DP105 in the patient's genome explain the testis differentation observed in this case. Failure of the patient's DNA to hybridize to the Y-5 probe shows that the primitive gonads can differentiate into testes even in the absence of this chromosome region. In contrast, a gene controlling spermatogenesis may exist in this region because the patient azoospermic
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Índice:
LILACS (Américas)
Assunto principal:
Aberrações dos Cromossomos Sexuais
/
Análise para Determinação do Sexo
/
Cromossomo Y
/
Sondas de DNA
Limite:
Adolescente
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
/
Congresso e conferência
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