Suppression of the IgE antibody response by Ascaris suum components: effect of x-irradiation
Braz. j. med. biol. res
;
24(6): 587-90, 1991. ilus
Artigo
em Inglês
| LILACS
| ID: lil-99493
ABSTRACT
The effect of X-irradiation on the supperession of IgE antibody responses induced by some of the Ascaris suum (ASC) components was analyzed in mice (7-week old A?Sn females). Treatment with 300 R 24h before immunization with 50 *g OVA and 200 *g ASC suppressive components abolished the damping effect on ati-OVA IgE antibody levels. The same effect was observed on the anti-ASC IgE antibody response obtained in mice injected with 200 *g ASC immunogenic plus 200 *g ASC suppressive components. Moreover, the failure of suppressive components to induce an IGE anti-ASC antibody response on their own was also abolished by X-irradiation. These results indicate that the suppressive components are able to elicit an IgE antibody response, but simultaneously activate a regulatory mechanism which suppressive both the homologous (anti-ASC) and heterologous (anti-OVA) antibody formation
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Índice:
LILACS (Américas)
Assunto principal:
Ascaris
/
Imunoglobulina E
/
Anticorpos Anti-Helmínticos
/
Tolerância Imunológica
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
/
Congresso e conferência
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