Involvement of PAF-acether and eicosanoids in adrenaline-induced pulmonary edema in mice
Braz. j. med. biol. res
;
24(3): 319-21, mar. 1991. tab
Artigo
em Inglês
| LILACS
| ID: lil-99571
ABSTRACT
The participation of platelet-activating factor (PAF,PAF-acether) in a mouse model of pulmonary edema was studied using specific antagonists.Mice were treated before induction of edema with the PAF antagonists BN52021 (10mg/kg, ip), PCA 4248 (10 mg/kg, po) or WEB2170 (10mg/kg, ip),the lipoxygenase inhibitor EP10161 (10 mg/kg,ip),the cyclo-oxygenase inhibitor aspirin (250 mg/kg,po), or with the mixed cyclo-lipoxygenase inhibitor BW755C(50 mg/kg, ip).The test drugs were administered to animals either 30 min (When the ip route was used) or 60 min (when given po) prior to the induction of pulmonary edema.Pulmonary edema was induced by intravenous administration of adrenaline (2 mg/kg). When the lung-body index was usedas thecriterion for comparision between groups,BN52021, PCA4248 and WEB2170 were found to have no significant effect on pulmonary edema. In contrast, EP10161, aspirinand BW755C significantly inhibited pulmonary edemaby 49%,30% and 27%,respectively. The results suggest that arachidonate metabolites are likely to play a major roe in adrenaline-induced pulmonary edema in mice, whereas PAF-acether does not seem to play an important role in this model
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Edema Pulmonar
/
Fator de Ativação de Plaquetas
/
Eicosanoides
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS