Comparison of ondansetron, dexamethasone, ondansetron plus dexamethasone and placebo in the prevention of nausea and vomiting after laparoscopic tubal ligation.
J Indian Med Assoc
;
2003 Nov; 101(11): 638, 640, 642
Artigo
em Inglês
| IMSEAR
| ID: sea-101282
ABSTRACT
Laparoscopic tubal ligation is associated with an appreciably high rate of postoperative nausea and vomiting. This study was designed to compare the effectiveness of ondansetron, dexamethasone, ondansetron plus dexamethasone or placebo in the prevention of postoperative nausea and vomiting in patients after laparoscopic tubal ligation. In a prospective, randomised, double blind placebo controlled trial, 160 ASA I-II females received one of four regimens; ondansetron 4 mg, dexamethasone 8 mg, ondansetron 4 mg plus dexamethasone 8 mg or placebo (n=40 each) intravenously immediately before induction of anaesthesia. Patients were then observed for 24 hours postoperatively. The incidence of emetic episodes in the ondansetron with dexamethasone group was lower than in the placebo (p<0.001) and ondansetron (p=0.091) and dexamethasone (p=0.143) groups. A complete response (as no postoperative nausea and vomiting) was achieved in 60% of patients given ondansetron, 63% of the patients given dexamethasone, 78% of patients given ondansetron with dexamethasone and 37% of patients received placebo. The prophylactic use of ondansetron with dexamethasone is more effective in preventing postoperative nausea and vomiting.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Procedimentos Cirúrgicos em Ginecologia
/
Feminino
/
Humanos
/
Dexametasona
/
Método Duplo-Cego
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Ondansetron
/
Laparoscopia
/
Náusea e Vômito Pós-Operatórios
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Revista:
J Indian Med Assoc
Ano de publicação:
2003
Tipo de documento:
Artigo
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