Growth hormone in turner syndrome.
Indian Pediatr
;
2006 Mar; 43(3): 236-40
Artigo
em Inglês
| IMSEAR
| ID: sea-10186
ABSTRACT
We assessed the effect of one year of therapy with recombinant Human Growth Hormone (rhGH) on growth velocity of 16 Indian girls with Turner Syndrome (TS) in a prospective, open trial. Patients received rhGH in a dose of 1 IU (0.3 mg)/kg/week. The mean pretreatment height was 117.1 cms (Z score minus 3.4), height velocity was 3.8 cm per year (Z score minus 2.4), and predicted height was 140 cm. At the end of therapy mean height was 123.9 (Z score minus 3.1), height velocity was 6.7 cm per year (Z score + 1.7), and the predicted height was 142.4 cm. The increment in height velocity with growth hormone therapy was statistically significant (P value = 0.001) and the mean increment in predicted height was 2.4 cm. Our study shows that girls with TS in India benefit from therapy with rhGH.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Síndrome de Turner
/
Proteínas Recombinantes
/
Feminino
/
Humanos
/
Criança
/
Estudos Prospectivos
/
Adolescente
/
Hormônio do Crescimento Humano
/
Crescimento
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2006
Tipo de documento:
Artigo
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