A study on the effects of diclofenac sodium and etoricoxib in the treatment of osteoarthritis.
J Indian Med Assoc
;
2007 May; 105(5): 260-2
Artigo
em Inglês
| IMSEAR
| ID: sea-103064
ABSTRACT
Diclofenac sodium, a non-selective cyclo-oxygenase inhibitor and etoricoxib, a selective cyclo-oxygenase-2 inhibitor have been widely used in treatment of patients with osteo-arthritis. Five hundred and eighty-five patients with uncomplicated knee osteo-arthritis were randomly allocated into 3 equal groups and received either diclofenac sodium, etoricoxib or placebo in a double-blind manner. The response in both the drug groups was comparable and much more than placebo group. The study shows that etoricoxib provides better clinical efficacy and gastro-intestinal tolerability in osteo-arthritis in comparison to diclofenac sodium presumably due to the selective inhibition of cyclo-oxygenase-2 by etoricoxib.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piridinas
/
Sulfonas
/
Feminino
/
Humanos
/
Masculino
/
Diclofenaco
/
Método Duplo-Cego
/
Resultado do Tratamento
/
Inibidores de Ciclo-Oxigenase
/
Adulto
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
J Indian Med Assoc
Ano de publicação:
2007
Tipo de documento:
Artigo
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