Current perspective in insulin therapy in the management of diabetes mellitus.

ABSTRACT

Insulin therapy since its discovery in 1922 is effective in restoring normoglycaemia, suppressing ketogenesis, delaying or arresting diabetic complications. The commonest indication for regular insulin therapy in type-2 diabetes is oral hypoglycaemic agent (OHA) failure. Regular insulin therapy is also indicated in patients of diabetes associated with renal or hepatic disease where OHA is contra-indicated. Different types and species of insulin have different pharmacological properties. There are several methods of insulin administration. Efficacy of human insulin has been proved beyond doubt. However, there is no reason to believe that animal insulin is inferior to human insulin.