Prophylactic theophylline infusion for prevention of apnea of prematurity.
Indian Pediatr
;
1992 Nov; 29(11): 1359-63
Artigo
em Inglês
| IMSEAR
| ID: sea-10324
ABSTRACT
To assess if there was any advantage in the prophylactic use of theophylline to prevent apnea in preterms, we treated 56 preterms (Group A) < 34 weeks gestation with theophylline infusion and compared these with 25 age and weight matched preterms (Group B) who received no therapy. Aminophylline (25 mg/ml) was infused from admission in all neonates (group A) at rates ranging 0.2 to 0.38 mg/kg/h and blood levels estimated on an Abbots TDX analyser by Fluorescence Polarization Immunoassay, after 5 days infusion. All neonates (Groups A + B) were monitored on a Corometric 505 neonatal monitor. In Group A, 1/48 developed primary apnea while in Group B, 4-21 had primary apnea (p < 0.05). Serum theophylline ranged from 2.3 to 39.5 micrograms/ml with a mean of 12.7 micrograms/ml. The mean serum level of theophylline in 4 cases who exhibited clinical evidences of toxicity was 30.1 micrograms/ml. A statistically significant difference (p < 0.05) was noted in birth weight and serum level inspite of similar infusion rates of theophylline. A linear correlation r = 0.65 was noted between serum level and infusion rate. Multivariate regression analysis, between birth weight and gestational age to serum level, showed a linear correlationship only between birth weight and serum level (r = 0.45).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Apneia
/
Teofilina
/
Peso ao Nascer
/
Infusões Intravenosas
/
Humanos
/
Recém-Nascido
/
Estudos Prospectivos
/
Aminofilina
/
Doenças do Prematuro
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1992
Tipo de documento:
Artigo
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