Effects of substance P on spontaneous contraction in the flexure region of the guinea pig colon.
Artigo
em Inglês
| IMSEAR
| ID: sea-1036
ABSTRACT
Effects of Substance P on spontaneous contractions of the circular muscle of the flexure region of guinea pig colon were studied by mechanical tension recording. Substance P (3 nM-10 nM) produced tonic contraction associated with phasic activities but the contraction was found stronger at higher concentration. Verapamil (3 microM), a voltage dependent L-type Ca(2+) channel blocker completely blocked the spontaneous activities and also Substance P induced contraction. These results suggest that Substance P produce contraction by Ca(2+) influx and the Ca(2+) influx occurs by activating verapamil sensitive Ca(2+) channel.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fatores de Tempo
/
Feminino
/
Masculino
/
Bloqueadores dos Canais de Cálcio
/
Verapamil
/
Substância P
/
Receptores de Taquicininas
/
Colo
/
Modelos Animais
/
Cobaias
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
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