The efficacy of topical administration of brimonidine to reduce ischaemia in the very early stage of diabetic retinopathy in good controlled type-2 diabetes mellitus.
J Indian Med Assoc
;
2004 Dec; 102(12): 724-5, 729
Artigo
em Inglês
| IMSEAR
| ID: sea-104333
ABSTRACT
It is now proved that diabetic micro-angiopathy is caused by ischaemia at the capillary bed of retina due to reduced capillary blood flow in long standing type-2 diabetes mellitus. Deranged metabolic process due to chronic hypoxia at the tissue level produces visual and vascular dysfunction. Brimonidine tartrate, an alpha-2 agonist which is commonly used in glaucoma to protect retinal ganglion cells from pressure related ischaemia induced cell apoptosis, is administered in very early stage of non-proliferative diabetic retinopathy to reduce ischaemia at the capillary bed of retina. Improved visual acuity and decreased micro-aneurysm formation, which indicate elimination of ischaemic stimulus at the tissue level, are seen in long standing type-2 diabetes mellitus.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Quinoxalinas
/
Fatores de Tempo
/
Visão Ocular
/
Glicemia
/
Humanos
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Diabetes Mellitus Tipo 2
/
Retinopatia Diabética
/
Isquemia
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Revista:
J Indian Med Assoc
Ano de publicação:
2004
Tipo de documento:
Artigo
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