Effect of chitosan on lipid levels when administered concurrently with atorvastatin--a placebo controlled study.
J Indian Med Assoc
;
2005 Aug; 103(8): 418, 420
Artigo
em Inglês
| IMSEAR
| ID: sea-105432
ABSTRACT
In a placebo controlled trialthe lipid lowering effects of chitosan, a unique dietary fibre, was assessed when given along with atorvastatin 10 mg in patients with chronic coronary heart disease. Altogether 100 patients were studied. They were randomly allocated in two groups of 50 patients each. Patients of group A received atorvastatin 10 mg before dinner plus 2 g/day chitosan in two divided doses. The groupB patients received atorvastatin 10 mg plus placebo. Patients were followed up for a period of 6 weeks. There was significant reduction in mean body weight in group A patients (3.14% versus 1,29% of body weight, p<0.05). There was also a significant rise in HDL cholesterol value (3.8% versus 1.07%, p=0.02) in group A patients. However, there was no significant reduction in the mean values of total cholesterol, LDL cholesterol and triglyceride in the two groups, although group A patients showed marginally lower values.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirróis
/
Humanos
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Quitosana
/
Quimioterapia Combinada
/
Ácidos Heptanoicos
/
Lipídeos
/
HDL-Colesterol
/
LDL-Colesterol
/
Anticolesterolemiantes
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
J Indian Med Assoc
Ano de publicação:
2005
Tipo de documento:
Artigo
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