Pathophysiology of prediabetes.
J Indian Med Assoc
;
2005 Nov; 103(11): 594-5, 599
Artigo
em Inglês
| IMSEAR
| ID: sea-105612
ABSTRACT
Type 2 diabetic patients pass through a phase of impaired glucose tolerence and/or impaired fasting glucose known as 'prediabetic state'. Prediabetic state form a part of syndrome X, other components being obesity, hypertension, dyslipidaemia, hyperinsulinaemia and insulin resistance. The pathophysiology of prediabetes is similar to type 2 diabetes mellitus, two basic defects are insulin resistance and early beta cell failure. In prediabetes, the rapid oscillations of insulin secretion are lost and amplitude of large pulses are decreased. When insulin is delivered in a pulsatile fashion that mimics the normal rapid oscillation, its hypoglycaemic effects are greater. In prediabetes, the glycaemic excursions after each meal are high and early insulin responses to meals tend to be lower than normal but the second phase of insulin secretion is delayed and prolonged.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Estado Pré-Diabético
/
Glicemia
/
Humanos
/
Resistência à Insulina
/
Intolerância à Glucose
/
Progressão da Doença
/
Síndrome Metabólica
/
Diabetes Mellitus Tipo 2
/
Peptídeo 1 Semelhante ao Glucagon
/
Teste de Tolerância a Glucose
Idioma:
Inglês
Revista:
J Indian Med Assoc
Ano de publicação:
2005
Tipo de documento:
Artigo
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