Interaction of calcium channel blockers with different agonists in aorta from normal and diseased rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 109-19
Artigo
em Inglês
| IMSEAR
| ID: sea-106161
ABSTRACT
The interactions of calcium channel blockers (CCBs) with noradrenaline (NA), phenylephrine (PE), dopamine (DA) and KCl have been investigated in rat isolated aortic strip. In preparations from control and hypertensive (DOCA-saline) rats chronically treated with verapamil, nifedipine and diltiazem, there was partial inhibition of contractions to NA, PE and DA. However, with nimodipine, there was potentiation of responses. This could be related to the occurrence of different isoforms of L-type calcium channels. In preparations obtained from hyperthyroid rats the concentration-response curves of NA, PE and KCl were shifted to the right with depressed maximal response which could be secondary to the primary effect exerted on the heart. In preparations from L-thyroxine + nimodipine/nifedipine treated rats the concentration-response curves of NA, PE and KCl were shifted to the right and the maxima was depressed suggesting that this may be due to decreased alpha receptor density (NA and PE) and down-regulation of voltage operated channels (KCl).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aorta Torácica
/
Fenilefrina
/
Cloreto de Potássio
/
Ratos
/
Masculino
/
Agonistas dos Canais de Cálcio
/
Bloqueadores dos Canais de Cálcio
/
Dopamina
/
Norepinefrina
/
Ratos Wistar
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1996
Tipo de documento:
Artigo
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