An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 57-63
Artigo
em Inglês
| IMSEAR
| ID: sea-106182
ABSTRACT
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Compostos Organotiofosforados
/
Pentilenotetrazol
/
Ratos
/
Convulsões
/
Barbital
/
Comportamento Animal
/
Feminino
/
Masculino
/
Ratos Sprague-Dawley
/
Convulsivantes
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Artigo
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