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An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Indian J Physiol Pharmacol ; 2000 Jan; 44(1): 57-63
Artigo em Inglês | IMSEAR | ID: sea-106182
ABSTRACT
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Compostos Organotiofosforados / Pentilenotetrazol / Ratos / Convulsões / Barbital / Comportamento Animal / Feminino / Masculino / Ratos Sprague-Dawley / Convulsivantes Tipo de estudo: Estudo observacional Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Compostos Organotiofosforados / Pentilenotetrazol / Ratos / Convulsões / Barbital / Comportamento Animal / Feminino / Masculino / Ratos Sprague-Dawley / Convulsivantes Tipo de estudo: Estudo observacional Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2000 Tipo de documento: Artigo