Monoamine oxidase concentration in median eminence, pituitary and uterus of rat after estrogen and centchroman treatment.

ABSTRACT

Estradiol dipropionate (0.005 mg/kg) increased the monoamine oxidase levels in pituitary, median eminence and uterus of ovariectomized rats. Centchroman (3,4-trans-2, 2-dimethyl-3-phenyl-4-p-(-pyrrolidinethoxy)-phenyl-7 methoxy chroman, 1.25 mg/kg) decreased the enzyme levels in pituitary and median eminence but not in uterus. Centchroman, given to estradiol treated groups could not bring down the enhanced levels of the enzyme in the uterus.