Effect of lead exposure on plasma phenylbutazone levels in rats.
Indian J Physiol Pharmacol
;
1994 Jan; 38(1): 61-2
Artigo
em Inglês
| IMSEAR
| ID: sea-106223
ABSTRACT
The effect of lead exposure on phenylbutazone kinetics was studied in rats. The biological half-life (t1/2) of phenylbutazone was determined from the plasma level versus time curve in 3 groups of rats given (i) 10 mg/kg lead orally for 8 weeks (ii) 100 mg/kg single oral dose and (iii) no lead, after oral administration of 100 mg/kg phenylbutazone to all rats. The t1/2 of the drug was found to be 33% lower on chronic lead exposure and 46% higher on acute exposure than in unexposed control rats. This variation in the t1/2 values of the two different groups of rats indicates that probably phenylbutazone metabolism varies with the period of lead exposure.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Espectrofotometria Ultravioleta
/
Masculino
/
Fenilbutazona
/
Meia-Vida
/
Intoxicação por Chumbo
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1994
Tipo de documento:
Artigo
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