Effect of physostigmine and atropine on the single-trial passive avoidance response in rats.
Indian J Physiol Pharmacol
;
1982 Jul-Sep; 26(3): 201-6
Artigo
em Inglês
| IMSEAR
| ID: sea-106227
ABSTRACT
Rats received a single training trial on an inhibitory avoidance (passive avoidance) task and retention trials 24 hr (R-I) and 48 hr (R-II) later, in a special two-chambered apparatus, and the mean step-through latency was determined. The animals were given the drug, either pre-trial, pre-trial plus pre-retention, pre-retention or post-trial. Physostigmine (0.1 mg/kg, ip) and atropine (6.0 mg/kg, ip) had no effect on learning, but they adversely affected retention, particularly at 24 hr. The effect seems to involve central cholinergic mechanisms of retention.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fisostigmina
/
Ratos
/
Atropina
/
Aprendizagem da Esquiva
/
Animais
/
Memória de Curto Prazo
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1982
Tipo de documento:
Artigo
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