Antidotal efficacy of pyridinium oximes and cholineacetyltransferase inhibitors against organophosphorus intoxication in rodents.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 50-6
Artigo
em Inglês
| IMSEAR
| ID: sea-106293
ABSTRACT
In an attempt to develop effective antidote against organophosphorus intoxication, some new imidazole-pyridinium mono-oximes, long chain pyridinium mono-oximes and cholineacetyltransferase inhibitors were synthesised. These compounds were evaluated for their in vivo therapeutic protection and neuromuscular function studies in rodents. The results indicate that SPK-series oximes may be useful against sarin poisoning without any beneficial effect against VX (O-Ethyl S-2-NN-diisopropylaminoethyl methylphosphonofluoridate) intoxication. The cholineacetyltransferase (ChAT) inhibitors may not be of any help against any of the OP compounds studied in this study.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Compostos Organofosforados
/
Compostos Organotiofosforados
/
Oximas
/
Compostos de Piridínio
/
Ratos
/
Sarina
/
Masculino
/
Colina O-Acetiltransferase
/
Inibidores da Colinesterase
/
Ratos Wistar
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Artigo
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