Effect of dothiepin on nociceptive response in diabetic rats.
Indian J Physiol Pharmacol
;
1992 Apr; 36(2): 93-6
Artigo
em Inglês
| IMSEAR
| ID: sea-106301
ABSTRACT
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Ratos
/
Ratos Endogâmicos
/
Glicemia
/
Medição da Dor
/
Feminino
/
Masculino
/
Distribuição Aleatória
/
Análise de Variância
/
Diabetes Mellitus Experimental
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1992
Tipo de documento:
Artigo
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