Calcium channel blockers and the CVS reflex responses during lower body suction.
Indian J Physiol Pharmacol
;
1991 Oct; 35(4): 232-6
Artigo
em Inglês
| IMSEAR
| ID: sea-106369
ABSTRACT
Nine normal men (mean age 27.6 yr) were exposed to continuous lower-body suction pressure (LBSP) of -20 to -50 mmHg (for 5 min at each level) on four different occasions after having consumed a single oral therapeutic dose of either diltiazem, nifedipine, verapamil, or a placebo, randomly, in a single blind manner. The suction was applied at 12.30 pm in all experiments, while the medications were administered in such a manner so that their expected peak plasma levels would have been achieved at the time of suction application. The cardiovascular reflex effects commenced at a pressure of -30 mmHg, and peaked at -50 mmHg. The increases in the heart rate for all treatments at -50 mmHg was statistically similar (about 16-20 beats/min). The systolic BP fell by about 9 mmHg for the placebo experiments, and this change was not different from the changes produced by the 3 Calcium channel blocker treatments. The diastolic BP increase was about 3 mmHg. The Cardiac index did not vary significantly. Our results suggest that the commonly used Ca++ channel blockers do not adversely affect orthostatic tolerance.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Estimulação Física
/
Reflexo
/
Volume Sistólico
/
Pressão Sanguínea
/
Humanos
/
Masculino
/
Bloqueadores dos Canais de Cálcio
/
Sistema Cardiovascular
/
Fenômenos Fisiológicos Cardiovasculares
/
Método Simples-Cego
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1991
Tipo de documento:
Artigo
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