Antinociceptive activity of chromophoric chain substituted hemicyaninocolourants.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 144-8
Artigo
em Inglês
| IMSEAR
| ID: sea-106399
ABSTRACT
Some of the chromophoric chain substituted hemicyaninocolourants (CCHCs) were synthesized and confirmed on the basis of nitrogen analysis. These were tested for their antinociceptive activity in albino rats against tail flick technique and sodium chloride induced writhing test. Test compounds were given in graded doses (10, 20 and 50 mg/kg, intraperitoneally) and compared with morphine and aspirin as standard controls. Two compounds CCHC-1 and CCHC-2 showed antinociceptive activity in a dose-dependent manner in both the experimental models. The compound CCHC-3 did not exhibit antinociceptive activity to any significant extent.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Quinolinas
/
Ratos
/
Padrões de Referência
/
Relação Estrutura-Atividade
/
Cauda
/
Feminino
/
Masculino
/
Cloreto de Sódio
/
Anti-Inflamatórios não Esteroides
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1997
Tipo de documento:
Artigo
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