Cerebral Perfusion Abnormalities in Children with Autism and Mental Retardation A Segmental Quantitative SPECT Study.
Indian Pediatr
;
2009 Feb; 46(2): 161-4
Artigo
em Inglês
| IMSEAR
| ID: sea-10654
ABSTRACT
Autism is a severe developmental disorder, the biological mechanisms of which remain unknown. Hence we conducted this study to assess the cerebral perfusion in 10 children with autism and mental retardation. Five age matched normal children served as controls. These cases were evaluated by single photon emission computed tomography (SPECT) using Tc-99m HMPAO, followed by segmental quantitative evaluation. Generalized hypoperfusion of brain was observed in all 10 cases as compared to controls. Frontal and prefrontal regions revealed maximum hypoperfusion. Subcortical areas also indicated hypoperfusion. We conclude that children with autism have varying levels of perfusion abnormities in brain causing neurophysiologic dysfunction that presents with cognitive and neuropsychological defects.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Transtorno Autístico
/
Processamento de Imagem Assistida por Computador
/
Humanos
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Circulação Cerebrovascular
/
Criança
/
Pré-Escolar
/
Transtornos Cognitivos
/
Cérebro
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2009
Tipo de documento:
Artigo
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