Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
Indian J Physiol Pharmacol
;
1992 Oct; 36(4): 276-8
Artigo
em Inglês
| IMSEAR
| ID: sea-106641
ABSTRACT
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfolipídeos
/
Ratos
/
Masculino
/
Hemoglobinas
/
Colesterol
/
Ratos Wistar
/
ATPase Trocadora de Sódio-Potássio
/
Contagem de Eritrócitos
/
Membrana Eritrocítica
/
Amiodarona
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1992
Tipo de documento:
Artigo
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