Nifedipine potentiates gabapentin antinociception in rats.
Indian J Physiol Pharmacol
;
2002 Apr; 46(2): 249-51
Artigo
em Inglês
| IMSEAR
| ID: sea-106644
ABSTRACT
To evaluate the involvement of Ca++ channels in Gabapentin antinociception. In healthy male albino rats formalin (50 microliters, 5%) was injected at the planter surface of the paw. Pain score was calculated. Antinociceptive effect of (10, 30 mg/kg) gabapentin and (3, 10 mg/kg) nifedipine alone and on co-administration of sub analgesic doses was studied 30 minutes after formalin injection and reduction in pain scores was calculated. Gabapentin (30 mg/kg) and nifedipine (10 mg/kg) reduced the pain score in formalin injected rats. Gabapentin (10 mg/kg) and nifedipine (3 mg/kg) given alone did not modify pain score, however, on co-administration they significantly reduced the pain score. Study provides evidence of involvement of Ca++ channels in gabapentin antinociception.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Medição da Dor
/
Masculino
/
Nifedipino
/
Ratos Wistar
/
Ácidos Cicloexanocarboxílicos
/
Sinergismo Farmacológico
/
Ácido gama-Aminobutírico
/
Aminas
/
Analgésicos
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2002
Tipo de documento:
Artigo
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