Endothelin-1 and carbachol: differences in contractile effects and myosin phosphorylation in lamb tracheal smooth muscle.
Indian J Physiol Pharmacol
;
1993 Jul; 37(3): 183-8
Artigo
em Inglês
| IMSEAR
| ID: sea-106714
ABSTRACT
Endothelin-1 is a new potent vasoconstrictor peptide produced by the endothelial cells. The contractile effects of endothelin-1 (ET-1) were compared with those of cabachol in lamb tracheal smooth muscle. Equimolar concentrations (10(-6)M) of endothelin 1 and carbachol elicit rapidly rising isometric tension which is maintained indefinitely in a steady state when fibres are stimulated with carbachol. Fibre strips exposed to ET-1 cannot maintain peak isometric force beyond 15-20 min and instead these exhibit a decline in tension towards near relaxed state. In addition to an early transient relaxation, ET-1 stimulation results in a 20,000 Da myosin light chain phosphorylation pattern different from that of carbachol stimulation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosforilação
/
Traqueia
/
Carbacol
/
Ovinos
/
Endotelinas
/
Miosinas
/
Contração Isométrica
/
Animais
/
Contração Muscular
/
Músculo Liso
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1993
Tipo de documento:
Artigo
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