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Cytotoxicity of the acetylated oil of Semecarpus anacardium Linn. f.
Indian J Physiol Pharmacol ; 1983 Apr-Jun; 27(2): 166-70
Artigo em Inglês | IMSEAR | ID: sea-106742
ABSTRACT
The cytotoxic effects of acetylated oil of Semecarpus anacardium nuts on the cells of P388 lymphocytic leukemia were tested in vitro. The product was tested at the concentrations ranging from 15-75 micrograms/ml. The cell kill was observed as early as three hr after the treatment. The effects of acetylated oil on the biosynthesis of DNA, RNA and protein using labelled thymidine, uridine and leucine respectively showed that the product inhibited the biosynthesis of all the three. This was indicated by the inhibition of the incorporation of their precursors. The uptake of 3H-thymidine was inhibited 15 min after treatment; while that of 3H-uridine and 14C-leucine took 30 and 45 min respectively. Since the S. anacardium oil was unstable due to air-oxidation, the studies were confined to its acetylated product.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Acetilação / Fatores de Tempo / Feminino / Masculino / DNA de Neoplasias / RNA Neoplásico / Óleos / Leucemia P388 / Índia / Animais País/Região como assunto: Ásia Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1983 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Acetilação / Fatores de Tempo / Feminino / Masculino / DNA de Neoplasias / RNA Neoplásico / Óleos / Leucemia P388 / Índia / Animais País/Região como assunto: Ásia Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1983 Tipo de documento: Artigo