Study on modification of hypoglycaemic effect of quinine by doxycycline in albino rats.

ABSTRACT

Hypoglycemia has been reported to occur in the patients and animals infected with various species of plasmodium (1). The use of quinine has been associated with significant decrease in blood sugar level, thus worsening the prognosis (2). In such a situation cautious thinking of possible drug interaction which may, further, aggravate the hypoglycemia is mandatory. But the data of the drug interaction of the combination of quinine and doxycycline in the treatment of chloroquine or multi-drug resistant falciparum malaria are not available. This study was aimed to find out whether this combination can cause more hypoglycemia when compared to quinine alone.