The antimyoclonic action of clonazepam through a GABA--independent mechanism.
Indian J Physiol Pharmacol
;
1989 Oct-Dec; 33(4): 243-6
Artigo
em Inglês
| IMSEAR
| ID: sea-106783
ABSTRACT
The present study investigates whether clonazepam exerts its antimyoclonic action through a GABA independent mechanism. We have studied the antimyoclonic effect of clonazepam and compared it with that of aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, against myoclonus induced by picrotoxin, a GABA receptor antagonist and allylglycine, a drug which inhibits synthesis and release of GABA. We have also investigated the effect of clonazepam against picrotoxin-induced myoclonus in rats pretreated with either AOAA or submyoclonic dose of allylgylycine. Clonazepam pretreatment inhibited both picrotoxin and allylglycine-induced myoelonus whereas AOAA was effective in inhibiting only picrotoxin-induced myoclonus. The protective effect of clonazepam against picrotoxin-induced myoclonus was potentiated by AOAA pretreatment. Moreover, clonazepam afforded protection against picrotoxin-induced myoclonus in rats pretreated with a submyoclonic GABA reducing dose of allylglycine. These findings indicate that a GABA independent mechanism may also be involved in the antimyoclonic action of clonazepam.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Picrotoxina
/
Ratos
/
Ratos Endogâmicos
/
Química Encefálica
/
Masculino
/
Clonazepam
/
Alilglicina
/
Ácido gama-Aminobutírico
/
4-Aminobutirato Transaminase
/
Ácido Amino-Oxiacético
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1989
Tipo de documento:
Artigo
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