Cardiovascular effects of a withanolide from Withania coagulans, dunal fruits.
Indian J Physiol Pharmacol
;
1983 Apr-Jun; 27(2): 129-34
Artigo
em Inglês
| IMSEAR
| ID: sea-106799
ABSTRACT
A new withanolide, with a unique chemical structure similar to the aglycones of the cardiac glycosides, with mol. wt. 488 6, m. p. 260-261 degrees, isolated from the fruits of Withania coagulans, was screened for cardiovascular effects. At doses of 5 mg/kg body weight, the withanolide produced a moderate fall of blood pressure in dogs (34 +/- 2.1, mm Hg) which was blocked by atropine and not by mepyramine or propranolol. In rabbit Langendorff preparation and ECG studies, it produced myocardial depressant effects but in perfused frog heart it produced mild positive inotropic and chronotropic effects.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Anuros
/
Coelhos
/
Ratos
/
Fluxo Sanguíneo Regional
/
Respiração
/
Pressão Sanguínea
/
Cães
/
Eletrocardiografia
/
Ergosterol
/
Coração
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1983
Tipo de documento:
Artigo
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