A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
Indian J Physiol Pharmacol
;
1993 Jul; 37(3): 235-7
Artigo
em Inglês
| IMSEAR
| ID: sea-106800
ABSTRACT
Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Propranolol
/
Ratos
/
Síndrome de Abstinência a Substâncias
/
Taquicardia
/
Pressão Sanguínea
/
Masculino
/
Ratos Wistar
/
Frequência Cardíaca
/
Hipertensão
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1993
Tipo de documento:
Artigo
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