Pharmacokinetics of phenytoin: unaltered by enalapril and amlodipine in rhesus monkeys.
Indian J Physiol Pharmacol
;
1999 Apr; 43(2): 251-4
Artigo
em Inglês
| IMSEAR
| ID: sea-106808
ABSTRACT
A cross over single and multiple dose study was carried out to find out pharmacokinetic interactions between diphynylhydantoin (DPH) (35 mg/kg, p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenitoína
/
Masculino
/
Enalapril
/
Anlodipino
/
Estudos Cross-Over
/
Interações Medicamentosas
/
Animais
/
Macaca mulatta
/
Anticonvulsivantes
/
Anti-Hipertensivos
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1999
Tipo de documento:
Artigo
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