Mitomycin C induced inhibition of adrenal steroidogenesis in female rats.
Indian J Physiol Pharmacol
;
1994 Apr; 38(2): 141-2
Artigo
em Inglês
| IMSEAR
| ID: sea-106950
ABSTRACT
Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase (delta 5 3 beta OHD) and glucose-6 phosphate dehydrogenase (G-6 PD) in the rat adrenal tissue. The treatment resulted in a fall in DNA content together with an accumulation of cholesterol and ascorbic acid in the gland. The results suggest a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ácido Ascórbico
/
Ratos
/
Esteroides
/
Feminino
/
DNA
/
Colesterol
/
Mitomicina
/
Ratos Wistar
/
Glândulas Suprarrenais
/
11-beta-Hidroxiesteroide Desidrogenases
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1994
Tipo de documento:
Artigo
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