Modulatory effects of diltiazem on inotropic responses to amrinone on rabbit isolated atria.
Indian J Physiol Pharmacol
;
1998 Apr; 42(2): 295-8
Artigo
em Inglês
| IMSEAR
| ID: sea-106967
ABSTRACT
The effect of pretreatment with graded concentration of diltiazem on the inotropic responses to amrinone were studied on isolated atria of rabbit. The responses to amrinone were modified by diltiazem in a biphasic manner; initial potentiation followed by inhibition. The potentiation is proposed to be due to synergistic rise in cytosolic calcium ion concentration by diltiazem and amrinone. The inhibition by diltiazem in higher concentration may be due to blockade of calcium ion influx and depletion of intracellular calcium ion from storage sites.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Inibidores de Fosfodiesterase
/
Coelhos
/
Bloqueadores dos Canais de Cálcio
/
Diltiazem
/
Amrinona
/
Cardiotônicos
/
Função Atrial
/
Sinergismo Farmacológico
/
Átrios do Coração
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1998
Tipo de documento:
Artigo
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