A study of some pharmacological actions of carbamazepine and sodium valproate.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 315-8
Artigo
em Inglês
| IMSEAR
| ID: sea-106969
ABSTRACT
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Anuros
/
Coelhos
/
Ratos
/
Sono
/
Fatores de Tempo
/
Temperatura Corporal
/
Carbamazepina
/
Gatos
/
Sistema Nervoso Central
/
Ácido Valproico
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1984
Tipo de documento:
Artigo
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