Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 326-30
Artigo
em Inglês
| IMSEAR
| ID: sea-107020
ABSTRACT
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Comportamento Estereotipado
/
Humanos
/
Masculino
/
Apomorfina
/
Catalepsia
/
Fenfluramina
/
Animais
/
Metanfetamina
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1984
Tipo de documento:
Artigo
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