The cardiac inotropic responses to insulin in the rat heart.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 346-50
Artigo
em Inglês
| IMSEAR
| ID: sea-107030
ABSTRACT
Insulin (5 to 40 I.U.) produced dose-dependent positive inotropic effect in the isolated rat heart. The responses to insulin were markedly inhibited in the presence of propranolol (1 . 1X10(-6) M). Insulin responses were markedly reduced in reserpine pretreated (5 mg/kg, i.p.) rats. Theophylline (4.4 mM), the phosphodiesterase inhibitor, potentiated the responses to insulin, whereas imidazole (20 mM), the phosphodiesterase stimulator inhibited the responses to insulin. The data suggest that the positive inotropic effects of insulin in rat heart is mediated through the release of cardiac catecholamines which stimulates beta-adrenoceptors. The final mediator of cardiac action seems to be cyclic-AMP.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Propranolol
/
Ratos
/
Estimulação Química
/
Teofilina
/
Feminino
/
Masculino
/
Interações Medicamentosas
/
Imidazóis
/
Insulina
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1980
Tipo de documento:
Artigo
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