A perspective of smooth muscle contractility through actions of vanadium compounds.
Indian J Physiol Pharmacol
;
1999 Jul; 43(3): 277-95
Artigo
em Inglês
| IMSEAR
| ID: sea-107090
ABSTRACT
Smooth muscle contraction has a characteristic step-response with successive additions of stimulating compounds, and instant reversal on withdrawing the stimulus, indicative of an equilibrium situation wherein continuous, rapid reactions are occurring. Vanadium compounds, ortho- and meta-vanadates, decavanadate and peroxovanadate, were found to contract a variety of smooth muscles. Their actions were analyzed with respect to activation of receptors, increase in the intracellular calcium concentration, and increase in calmodulin-dependent myosin light chain phosphorylation leading to contraction. A new perspective of smooth muscle contractility has emerged from the studies with vanadium compounds suggesting control mechanisms involving phosphorylation for contraction and redox for relaxation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredução
/
Fosforilação
/
Compostos de Vanádio
/
ATPase Trocadora de Sódio-Potássio
/
Receptores de Superfície Celular
/
Canais Iônicos
/
Animais
/
Potenciais da Membrana
/
Contração Muscular
/
Proteínas Musculares
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1999
Tipo de documento:
Artigo
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