Higher AUCs on oral administration of omeprazole and felodipine in Indian volunteers--are they clinically important?
Artigo
em Inglês
| IMSEAR
| ID: sea-107147
ABSTRACT
Bioavailability studies with single oral doses of omeprazole 20 mg (enteric coated formulation) and felodipine 10 mg (extended release formulation) were performed in Indian volunteers to confirm that adequate plasma concentrations are obtained in Indian subjects. Plasma samples were analysed by chromatographic methods. The AUCs of omeprazole were about 3 fold higher and those of felodipine 2 fold higher than AUCs reported in Western subjects. This has no toxicological implications with respect to omeprazole, but whether lower dose of omeprazole may be sufficient in Indian patients with acid related diseases would require acid inhibition studies. In the case of felodipine the higher AUCs in Indian subjects suggest a need for a lower strength formulation (2.5 mg) to fine-titrate the dosage to obtain optimal antihypertensive effects with minimal adverse effects.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Omeprazol
/
Humanos
/
Bloqueadores dos Canais de Cálcio
/
Disponibilidade Biológica
/
Felodipino
/
Administração Oral
/
Adolescente
/
Adulto
/
Antiulcerosos
Idioma:
Inglês
Ano de publicação:
1996
Tipo de documento:
Artigo
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