Effects of periodic weight support in a simulated weightless environment in preventing bone demineralisation.
Indian J Physiol Pharmacol
;
2003 Jan; 47(1): 81-6
Artigo
em Inglês
| IMSEAR
| ID: sea-107158
ABSTRACT
Anti Orthostatic Hypokinetic posture in rats by tail suspension for 15 days (d) simulates the deconditioning effects of weightlessness on the weight bearing bones. The present study evaluates the effects of daily 4 hour (h) weight support (WS) during simulated weightlessness (S-W) in preventing these changes. Adult male albino rats were divided into three groups as (i) Control (CON, n = 12), (ii) Hind limb unweighing by tail suspension for 15 d (HU, n = 18), (iii) HU with daily 4 h WS (4 HRWS, n = 11). After 15 d tibia from all the animals were removed and subsequently dried, ashed and then calcium content of the bones were determined. HU showed reductions in the water content by 35.8%, organic matrix by 12.2% and calcium content by 33.4% of tibia. 4 h WS during S-W resulted in complete prevention of water loss and organic matrix loss and partial prevention of the loss of calcium content. Calcium content of tibia in 4 HRWS remained 15.2% less as compared to CON. These findings indicate that 4 h WS is partially successful in preventing the demineralisation effects of S-W on weight bearing bone tibia.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Condicionamento Físico Animal
/
Ratos
/
Tíbia
/
Fatores de Tempo
/
Masculino
/
Suporte de Carga
/
Ratos Wistar
/
Simulação de Ausência de Peso
/
Contramedidas de Ausência de Peso
/
Desmineralização Patológica Óssea
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2003
Tipo de documento:
Artigo
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