Effects of oral lithium on the action of various C.N.S. active drugs.
Indian J Physiol Pharmacol
;
1996 Jul; 40(3): 241-4
Artigo
em Inglês
| IMSEAR
| ID: sea-107190
ABSTRACT
Effects of prolonged lithium administration was seen on the action of various psychoactive drugs in animals. Apomorphine induced pecking in pigeons increased significantly by lithium treatment for 14 days, from 1445.3 +/- 202.5 in control to 2785.8 +/- 205.8 in Gp. B. Haloperidol-induced catalepsy score in albino rats increased significantly following chronic lithium treatment compared to control. Chlorpromazine-induced hypothermia in rabbits was immediate but transient, while in lithium treated rabbits induction of hypothermia was delayed, sustained and of greater magnitude. This action of lithium may be mediated by increasing the permeability of blood-brain barrier, or enhancing the sensitivity of alpha-adrenoceptors in brain.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Columbidae
/
Psicotrópicos
/
Coelhos
/
Ratos
/
Feminino
/
Masculino
/
Apomorfina
/
Clorpromazina
/
Administração Oral
/
Sinergismo Farmacológico
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1996
Tipo de documento:
Artigo
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