Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
Indian J Physiol Pharmacol
;
2005 Jan; 49(1): 111-4
Artigo
em Inglês
| IMSEAR
| ID: sea-107285
ABSTRACT
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Selênio
/
Succinato Desidrogenase
/
Masculino
/
Administração Oral
/
Ratos Wistar
/
Curcumina
/
Inibidores Enzimáticos
/
L-Lactato Desidrogenase
/
Fígado
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2005
Tipo de documento:
Artigo
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