Neuropharmacological actions of labetalol.
Indian J Physiol Pharmacol
;
1979 Jan-Mar; 23(1): 39-43
Artigo
em Inglês
| IMSEAR
| ID: sea-107298
ABSTRACT
Labetalol, an alpha- and beta- adrenoceptor antagonist was investigated for its central nervous system effects in rats and mice. A marked reduction in the spontaneous motor activity with no concomittant muscle weakness was produced. The drug caused closure of eyelids in rats. Labetalol caused hypothermia and prolonged the pentobarbitone-induced hyposis. In animals trained for conditioned avoidance response the drug blocked the SCR in all the animals and CAR in a few number of animals. The drug did not protect the animals against electroshock convulsions. From the results it appears that labetalol is a central nervous system depressant.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pentobarbital
/
Ratos
/
Convulsões
/
Aprendizagem da Esquiva
/
Temperatura Corporal
/
Feminino
/
Masculino
/
Sistema Nervoso Central
/
Condicionamento Operante
/
Depressão Química
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1979
Tipo de documento:
Artigo
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