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Protective effects of Piper nigrum and Vinca rosea in alloxan induced diabetic rats.
Indian J Physiol Pharmacol ; 2005 Jan; 49(1): 65-71
Artigo em Inglês | IMSEAR | ID: sea-107347
ABSTRACT
In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks. These treatments lead to significant lowering of blood sugar level and reduction in serum lipids. The levels of antioxidant enzymes, catalase and glutathione peroxidase decreased in alloxan induced diabetic rats however these levels returned to normal in insulin, P. nigrum and V. rosea treated rats. There was no significant difference in superoxide dismutase activity in all groups compared to controls. Lipid peroxidation levels were significantly higher in diabetic rats and it was slightly increased in insulin, P. nigrum and V. rosea treated rats as compared to control rat. These results suggest that oxidative stress plays a key role in diabetes, and treatment with P. nigrum and V. rosea are useful in controlling not only the glucose and lipid levels but these components may also be helpful in strengthening the antioxidants potential.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Sementes / Masculino / Extratos Vegetais / Ratos Wistar / Catharanthus / Piper nigrum / Flores / Diabetes Mellitus Experimental / Animais Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Sementes / Masculino / Extratos Vegetais / Ratos Wistar / Catharanthus / Piper nigrum / Flores / Diabetes Mellitus Experimental / Animais Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2005 Tipo de documento: Artigo