Blockade by burimamide of the effects of clonidine on cardiac contractility phosphorylase activation and cyclic adenosine monophosphate in isolated guinea pig heart.
Indian J Physiol Pharmacol
;
1980 Apr-Jun; 24(2): 77-83
Artigo
em Inglês
| IMSEAR
| ID: sea-107403
ABSTRACT
Clonidine in a dose-range of 2.5 microgram to 80 microgram caused positive inotropic effect, which was accompanied by increase in the cyclic AMP levels and phosphorylase-activation of the isolated perfused guinea pig heart. Clonidine-induced biochemical and mechanical effects were blocked by burimamide, an H2-receptor antagonist Propranolol (1 x 10(-6)M), phentolamine (1 x 10(-6)M) or reserpine pretreatment, did not affect the clonidine responses on the perfused guinea pig heart. Clonidine reduced the 4-methyl-histamine (H2-agonist) responses of guinea pig heart. Our data suggest that the cardiac effects of clonidine may be due to stimulation of H2-type of receptors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosforilase a
/
Estimulação Química
/
Tioureia
/
Burimamida
/
Feminino
/
Masculino
/
Receptores Histamínicos H2
/
Clonidina
/
AMP Cíclico
/
Relação Dose-Resposta a Droga
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1980
Tipo de documento:
Artigo
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